Time control systems

Código SN03-E0230-I

VIEW:406 DATA:2020-03-20

Time control systems.

The human temporal system is probably linked to a counter or genetic code that determines the age that a human being must live. This factor is linked to the Hayfick limit, some researches analyze that these factors are closely linked to the size of the telomeres, some analyzes suppose the need to return to pluripotent cells, stem cells. Most animals have these codes or are limited by telomeres, but some animals do not have a time limit. They are considered eternal animals.

Among them we have Tardigrades, some bacteria, but Hydra, Medusa, and Planária stand out, where their telomeres remain constant. One of the great researches is in the development and application of telomerase, but its use can form or destroy cancer cells, so its use is extremely dangerous.

Even so, telomerase and the growth of telomeres cannot be proven to determine a control system in longevity, there are some tissues that do not show a decrease in telomerase even though they die in a living system.

So we have modification of the cells to pluripotent ones, or the use of telomerase, both extremely dangerous factors, and with their end in cancer formation.

Outside the context of modifying telomeres, we have some research products like resveratrol.

Resveratrol delays the age-dependent deterioration of locomotor activity and cognitive performance and reduces the expression of neurofibrillary degeneration in the brain, which has been suggested as a mimetic caloric restrictive potential. Acts as a SIRTUINA activator, resveratrol is a specific activator of human yeast substrate Sir2 and SirT1, resveratrol and enhances the deacetylation bond of peptide substrates containing Lys Fluor, resveratrol has no detectable effect on Sir2 in activity vivo, as measured by rDNA recombination, transcriptional silencing near telomeres, and lifetime. In the light of these results, the mechanism responsible for the putative resveratrol longevity effects should be reexamined.

http://www.ncbi.nlm.nih.gov/pubmed/15684413

http://www.ncbi.nlm.nih.gov/pubmed/16461283







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Tags

telomerase, longevide, sirtuin, resveratrol