IL-6 is a proinflammatory cytokine, polymorphism of Interleukin 6 to 174C / G has been linked to obesity and insulin resistance. Asp358Ala polymorphism, positively associated with abdominal obesity in T alleles, 174C / G polymorphism, and Pro12Ala polymorphism in the presence of C allele and A allele, respectively, reduces weight loss.
Thus such polymorphisms are possibly linked to obesity and difficulty in weight loss. The detection of these polymorphisms signals a greater difficulty in controlling obesity, and is linked to calorie consumption in relation to interleukin 6.
It should be noted on average that difficulty is not required to be obese, only if it is more predisposed to obesity than others who do not have such polymorphisms.
PPAR-activated receptors regulate the expression of several genes related to lipid and glucose metabolism. PPAR-gamma is predominantly expressed in adipose tissue and plays an important role in adipocyte differentiation and expression of various genes.
PPAR-gamma2 Pro12Ala polymorphism, a polymorphism associated with improved insulin sensitivity and protection against the development of type 2 diabetes mellitus.
Interaction between gene and nutrient of this polymorphism in relation to those exposed to a high consumption of saturated fat and trans fat, showed a higher incidence of diabetes mellitus.
Patients with the Ala Allele, reduced total and saturated fat consumption, and an increase in total fiber consumption, developed Diabete Melitus less frequently than those with the Pro allele.
Non-diabetic women with the Ala allele had a positive association between high consumption of eicosapentaenoic fatty acid from fish meat and better control of glucose metabolism-associated phenotypes.
Thus, in general, the greater reduction in saturated fat and elimination of trans fat favors the non-incidence of diabetes mellitus. Normally saturated fat reduction, and trans fat elimination, is linked to lower BMI groups than groups with high saturated fat consumption.
In all these polymorphisms, an individual with low saturated fat consumption, a high fiber diet, added to an active life and energy and nutrient needs, already exceeds the incidence of diabetes mellitus, if only the occasional reductions.
Thus polymorphisms are helpful to professionals who have to work as the problem. For those seeking prevention, the most comprehensive and complete prevention system is always better than the specific one.